More than 90 % of newly developed Active Pharmaceutical Ingredients (APIs) are poorly soluble. To get the full pharmacological potential of an API, one has to make sure that the drug will be dissolved in an appropriate time period as a prerequisite for its passive or active absorption in the GI tract of the patient.
To improve the solubility as well as the dissolution rate of poorly soluble APIs, one strategy is to reduce the API particle size to nano size. Due to that, the surface area of the API particles is strongly increased which results in a possible oversaturation. However, an increase of the API solubility and the dissolution rate leads to higher bioavailabilities, which may lead to lower therapeutic doses reduced adverse side effects as well as reduced costs.
The probably most important approach to obtain API nanoparticles is wet bead milling of aqueous API suspensions containing suitable additives for particle stabilization.
|12:00 - 13:00||Welcome and registration|
|13:00 - 14:00||Production of nano API suspensions |
Sven Hoffmann, Application Engineer, NETZSCH Vakumix GmbH, Weyhe
|14:00 - 15:00||Efficient and predictive screening tool – facilitation of the development of nanoparticulate formulations for oral, parenteral and topical applications |
Dr. Ansgar Bögershausen, Head of R&D, Losan Pharma GmbH
|15:00 - 15:30||Coffee break|
|15:30 - 16:30||Optimization and scale up of wet bead milling processes |
Dr. Stefan Mende, Manager of Technical and Scientific Communication, NETZSCH-Feinmahltechnik GmbH, Selb
|16:30 - 17:30||New surfactants in wet ball milling and an innovative embedding of Nanocrystals into a granulate matrix |
Dr. Matthias Rischer, Business Development & Development of Innovative Projects, Losan Pharma GmbH, Frankfurt
|19:00||Come together and Dinner|
|Bus-transfer at 8:15 a.m. to Losan Pharma GmbH, Weismüllersraße 50, 60314 Frankfurt a. Main|
Presentation at Losan Pharma laboratory: Production of suspensions with real nano API on
|Final discussion and end of the seminar at approx. 02:00 p.m.|
|Date:||26. - 27.11.2019|
|Duration of the course:||2 days|
|Fee:||EUR 500.00 + VAT|
|Venue:||Congress Hotel Lindner, Hoechst|
|Course charge contains:|| |
|26 Nov – 27 Nov 2019||Hoechst||Germany||Registrar|