Production and Characterization of Nanosuspensions with Active Pharmaceutical Ingredients

More than 90 % of newly developed Active Pharmaceutical Ingredients (APIs) are poorly soluble. To get the full pharmacological potential of an API, one has to make sure that the drug will be dissolved in an appropriate time period as a prerequisite for its passive or active absorption in the GI tract of the patient.

To improve the solubility as well as the dissolution rate of poorly soluble APIs, one strategy is to reduce the API particle size to nano size. Due to that, the surface area of the API particles is strongly increased which results in a possible oversaturation. However, an increase of the API solubility and the dissolution rate leads to higher bioavailabilities, which may lead to lower therapeutic doses reduced adverse side effects as well as reduced costs.

The probably most important approach to obtain API nanoparticles is wet bead milling of aqueous API suspensions containing suitable additives for particle stabilization.

Programm | 1st Day - Theoretical background

12:00 - 13:00 Welcome and registration
13:00 - 14:00 Production of nano API suspensions
Sven Hoffmann, Application Engineer, NETZSCH Vakumix GmbH, Weyhe
14:00 - 15:00 Efficient and predictive screening tool – facilitation of the development of nanoparticulate formulations for oral, parenteral and topical applications
Dr. Ansgar Bögershausen, Head of R&D, Losan Pharma GmbH
15:00 - 15:30 Coffee break
15:30 - 16:30 Optimization and scale up of wet bead milling processes
Dr. Stefan Mende, Manager of Technical and Scientific Communication, NETZSCH-Feinmahltechnik GmbH, Selb
16:30 - 17:30 New surfactants in wet ball milling and an innovative embedding of Nanocrystals into a granulate matrix
Dr. Matthias Rischer, Business Development & Development of Innovative Projects, Losan Pharma GmbH, Frankfurt
19:00 Come together and Dinner


Program | 2nd Day - Practical Workshop

Bus-transfer at 8:15 a.m. to Losan Pharma GmbH,  Weismüllersraße 50, 60314 Frankfurt a. Main

Presentation at Losan Pharma laboratory: Production of suspensions with real nano API on
NETZSCH machines

  • DeltaVita® 1
  • KappaVita 5
  • DeltaVita® Mini
Final discussion and end of the seminar at approx. 02:00 p.m.


Seminar information

Date: 26. - 27.11.2019
Duration of the course: 2 days
Attendance: max. 40
Fee: EUR 500.00 + VAT
Venue: Congress Hotel Lindner, Hoechst
Course charge contains:  
  • 1 overnight stay with breakfast
  • Catering during the seminar
  • Dinner
  • Transfer from the hotel to Losan Pharma
  • Seminar documents
  • NETZSCH Compendium


Flyer Workshop| Production and Characterization of Nanosuspensions with Active Pharmaceutical Ingredients

Tarih Şehir Ülke
26 Nov – 27 Nov 2019 Hoechst Germany Kayıt ol