Webinar Series: Pharma & Cosmetics

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From R&D to Production of Nano-API-Suspensions


More than 90 % of newly developed Active Pharmaceutical Ingredients (APIs) are poorly soluble. To get the full pharmacological potential of an API, one has to make sure that the drug will be dissolved in an appropriate time period as a prerequisite for its passive or active absorption in the GI tract of the patient. To improve the solubility as well as the dissolution rate of poorly soluble APIs, one strategy is to reduce the API particle to nano size. Due to that, the surface area of the API particles is strongly increased which results in a possible oversaturation.

However, an increase of the API solubility and the dissolution rate leads to higher bioavailabilities, which may lead to lower therapeutic doses reduced adverse side effects as well as reduced costs. The probably most important approach to obtain API nanoparticles is wet bead milling of aqueous API suspensions containing suitable additives for particle stabilization.

This webinar shows different technologies how to reduce API particle to nano size.

Tuesday, 12.10.2021
09:00 AM - 09:30 AM CEST

Lecture language: English

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Thursday, 14.10.2021
03:00 PM - 03:30 PM CEST

Lecture language: English

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Dispersing and Homogenizing of highly viscous products


The production of highly viscous products in the pharmaceutical and cosmetic industry is facing different challenges. Products like creme, ointments, gel, toothpaste and lipstick has multiple requirements on the production process. Based on the GMP design the system shall be able to handle challenges like multiple vessel process, powder induction, homogenizing, hot-cold-process, cleaning-in-place (CIP) and sterilization-in-place (SIP). Reproducibility and data recording are also part of the whole process. A computer simulation helps to develop the right configuration of the system to reach the production targets.

This webinar shall provide a view into the environment and the conditions when producing highly viscous products, as well as some fundamentals for the selection of production machinery and the suitable accessories.

Tuesday, 19.10.2021
09:00 AM - 09:30 AM CEST

Lecture language: English

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Thursday, 21.10.2021
03:00 PM - 03:30 PM CEST

Lecture language: English

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